Ruud van Nistelrooy and Arjen Robben have been named in the Dutch squad for the World Cup European Zone Group One qualifiers against Romania and Armenia after recovering from injuries.
The Premier League forwards missed last month's friendly match with England but could start in Romania on March 26 and in Eindhoven against Armenia on March 30.
Van Nistelrooy made his comeback for Manchester United three weeks ago after an Achilles problem while Robben has still not played for Chelsea since breaking his foot in early February.
"Our medical staff travelled to London to visit Robben and they informed me that Robben was fit and ready to play matches," Dutch coach Marco Van Basten told a news conference on Friday.
"We expect that he will play this weekend and then we also will have contact with Chelsea. I picked Robben because he is a real left winger and I don't have any other real opportunities for that position."
Van Basten also picked three new names in his 20-man squad, calling up AZ Alkmaar winger Martijn Meerdink and Ajax youngsters Ryan Babel and Hedwiges Maduro.
Van Basten dropped right winger Romeo Castelen in favour of Meerdink after the Alkmaar forward impressed against Shakhtar Donetsk's Romanian defender Razvan Rat in the UEFA Cup.
"Rat is likely to play the left defensive position for Romania and Meerdink did very well against him," added Van Basten.
Van Basten defended his decision to select 20-year-old Maduro, who has played just two matches for Ajax's first team, and 18-year-old Babel, who has appeared in 10 games including three as starter.
"The first criteria to pick someone is his specific football skills," he said. "It is nice when players are experienced but it is not necessary. Maduro is a controlling midfielder who can be useful in my team while Babel has specific qualities as striker."
The inexperienced Ajax duo's call up suggests Van Basten has closed the door on Patrick Kluivert and Clarence Seedorf.
"They are not my first choices for their positions and as well as a good result in the coming matches I am also keeping my eye on the future," Van Basten added.
Manchester United cruised into the FA Cup semi-finals with a 4-0 win over Southampton in which keeper Paul Smith again performed heroics.
Young stopper Smith got the nod despite the return to fitness of Antti Niemi - and despite conceding four goals he prevented what could have been an embarrassing scoreline with a string of fine saves.
Smith was beaten after just two minutes, when Roy Keane thumped home a deflected effort, and then kept United at bay until the stroke of half-time when Cristiano Ronaldo clinically volleyed in a crisp strike.
The keeper had denied Wayne Rooney, Quinton Fortune and Ruud van Nistelrooy - but he was beaten again on 48 minutes when Scholes lashed a close-range effort into the back of the net.
Smith then tipped van Nistelrooy's angled volley over the bar on 56 and saved Rooney's bullet header on 78.
But Scholes headed in a cross from van Nistelrooy three minutes from time to wrap up a comfortable victory for Sir Alex Ferguson's troops.
Ruud van Nistelrooy has shouldered part of the blame for Manchester United's Champions League demise.
The Dutchman, clearly still short of match fitness after his lengthy absence with an Achilles complaint, wasted two chances at the San Siro but did not manage to test AC Milan keeper Dida with either of them as United slumped to a 2-0 aggregate defeat.
The first opportunity, just before half-time, was crucial as it came before the header from Hernan Crespo that eventually sealed the Italian giants' win.
And with Ryan Giggs smashing a shot against a post a few minutes earlier, van Nistelrooy found it easy to identify where it had all gone wrong for the Old Trafford men.
"If we had scored first, it could have been a different game," said the prolific Dutchman, who has scored 36 goals for the Red Devils in just four European campaigns.
"Ryan had a chance and I had a couple of chances but we didn't take them and that was the story of the game.
"It is a very disappointing result for us. We gave it everything but it wasn't meant to be."
Manager Sir Alex Ferguson now faces a dilemma over whether to play van Nistelrooy in the FA Cup sixth-round clash at Southampton on Saturday, a tie that has suddenly taken on huge importance.
Victory would allow the holders to at least look forward to snatching some silverware from an otherwise disappointing campaign, just as they did 12 months ago.
But defeat would realistically leave United with nothing more to play for than the battle with Arsenal to finish second in the Premiership and avoid an early entrance into next season's Champions League.
Sadness was etched onto all United faces as they headed out of Milan last night, but van Nistelrooy is convinced over the two games the Red Devils proved they remain among Europe's elite and the lessons learned can only help the younger members of their squad.
"We have shown we are not far away," said van Nistelrooy.
"Our side is much younger than Milan's and at decisive moments they used that extra experience.
"There are definitely a few lessons we can learn from this defeat and a few things we can improve on to achieve what we want to achieve."
Ruud van Nistelrooy was disappointed to see United ousted from the Champions League with a mirror-image second-leg defeat to AC Milan in the San Siro.
Hernan Crespo's two goals over the two games divided the sides, but van Nistelrooy was left to rue the Reds' missed half-chances.
Ruud said: "If we had scored first through Giggsy's chance or my chance then it would have been a different game definitely. But overall I think we did play well and gave everything. I think it wasn't meant to be today.
"The result was very disappointing. To come here at 1-0 down was a hard one to take but I think we gave everything we had. Unfortunately they scored the first one and really made it difficult for us."
However, van Nistelrooy insists the silver lining to the heartbreaking defeat is that United's talented youngsters have learned another valuable lesson against one of Europe's most experienced sides.
He said: "We have a younger side than Milan. I think the experience they have was an advantage for them, and the decisive moments showed that. For us now, we learned and the younger lads got great experience and we can go on and build on this I think.
"We showed we're not far off and there's a few things to improve and that's what we want to achieve."
Meanwhile, skipper Roy Keane displayed his usual candour in admitting that shot-shy United didn't deserve to progress, having failed to properly test Milan keeper Dida over the two legs.
He said: "I think not to have scored over the two legs and not to have tested their keeper a bit more is more disappointing than anything else. If you don't score in the two games you don't deserve to go through."
Van Nistelrooy back in Dutch squad
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